Decoding Kinesinís Asymmetric Walk Through Microtubule Rotation Experiments

Paul Simonson, Medicine, UIUC

Kinesins constitute a family of proteins that is essential to a variety of movement functions within cells, from cytokinesis to jetting cargoes through the enormous length (from a molecular scale) of the axons in the body. The mechanics of how these tiny protein motors function have fascinated biophysicists since their discovery in 1985. This poster describes our recent efforts to elucidate the mechanism by which conventional kinesin maintains a rotation-less walk while transporting its cargo along microtubules.