Consistencies of Myocyte Flow Source and Developed Pressure Models of Cardiac Function

Edward Marcus 1, Damian Craig 2, Ira Cheifetz 3, Daya Samantapudi 4, and Rupak Mukherjee 5

1 Children’s Hospital Boston, Department of Cardiology
2 Duke University Medical Center, Division of Cardiothoracic Surgery
3 Duke University Medical Center, Division of Pediatric Critical Care Medicine
4 John Hopkins University, Division of Cardiology
5 Medical University of South Carolina, Department of Surgery, Cardiothoracic Surgery Research

With a myocyte as the source of cardiac outflow, consistencies can be predicted between a myocyte generated flow model, and more traditional cardiac models developed in the context of pressure measurement. Well known properties of traditional pressure models include linearity of developed pressure with volume, and temporal uniformity of pressure when normalized to time and amplitude of peak.
We have applied a myocyte flow source model to examine traditional pressure model properties. With a cell source, the Peak Pressure vs Volume calculated over volume range 10 mL <= V<= 50 mL yields linear regressions R2 = .994, .998, .999 in three contractile states. Additionally, a uniformity of cell shortening motion normalized to peak stroke is observed as a physiological basis of similar uniformities known to occur with developed pressure. We conclude the traditional model of cardiac pressure development is consistent with flows originating from the shortening action of the mycocyte.