A Hydrophobic Eigenmode Approach to Peptide Analysis and Design

Arnold Mandell, Vice President and Director of Research, Cielo Institute

Our program of research moves counter-current to today's cutting edge proteonomics which seeks to use genes to replace dysfunctional or absent proteins. We make a try at modifying the dynamical properties of malfunctioning proteins by binding them with a recognized-as-similar-to-themselves peptides via hydrophobic eigenmodes that fold in with their protein target. The protein's breathing, roiling, turublent dance is cooperatively altered in these peptide-protein conjugates. We demonstrate this approach through the correction of the kinetic properties of the D2 dopamine receptor in rat strains with congenitital "attention deficit hyperactivity disorder", ADHD.